Beefalo
When settlers first brought cattle to the New World in the 18th century, they inadvertently crossed bison and cattle. They were later crossbred more purposefully, but a few of them escaped. There are now wild herds of beefalo near the Grand Canyon. They wreak havoc by emptying watering holes and generally making a mess wherever they go! It is now up for debate whether we should capture them.
Tigon
The Tigon was created by crossing a male tiger and a female lion. The sex of the parents is what distinguishes it from a Liger. You’d think the tigon and the liger would look alike, but they’re not. Tigons are not as large as ligers and do not develop dwarfism. On average, they are healthier than their close relatives.